Rapid Reduction of Severe Hypertriglyceridemia and Hyperglycemia in Metabolic Syndrome through Ayurvedic Intervention: A Case Report
Keywords:
Ayurveda, Hypertriglyceridemia, Metabolic Syndrome, Prameha, Type 2 diabetes mellitusAbstract
Type 2 diabetes mellitus with severe hypertriglyceridemia represents a critical metabolic emergency carrying a high risk of acute pancreatitis and cardiovascular events. Conventional pharmacological approaches may require weeks to achieve glycemic and lipid targets. Ayurveda offers multitarget interventions that have the potential for rapid metabolic restoration. Here is a case report of a 50-year-old male with known hypertension (4 years) and dyslipidemia presenting with complaints of nocturia, polydipsia, and craving for sweet and cold foods. Investigations revealed hyperglycemia and hypertriglyceridemia, but the patient refused to take conventional medicines. A 15-day Ayurvedic treatment protocol comprising Punarnavashtak Kwath, Madhumehari Churna, Paniya Kalpana of Daruharidra, Guduci, Musta, and Arogyavardhini Vati, combined with prescribed dietary modifications, resulted in rapid clinical improvement. At the 15-day follow-up, all parameters, including fasting blood sugar and triglyceride levels, were within normal limits. This case demonstrates the potential of a structured Ayurvedic protocol to achieve rapid, clinically significant metabolic correction in severe hyperglycemic–dyslipidemia crisis.
References
1. Chandola HM, Kajaria D. Prameha chikitsa adhyaya. In: Baghel MS, Deole YS, Basisht G, editors. Charak samhita new edition. 1st ed.Jamnagar: CSRTSDC; 2020. p. 79.
2. Shams ME, Al-Gayyar MM, Barakat EA. Type 2 diabetes mellitusinduced hyperglycemia in patients with NAFLD and normal LFTs: Relationship to lipid profile, oxidative stress and pro-inflammatory cytokines. Sci Pharm. 2011;79(3):623-34. doi: 10.3797/ scipharm.1104-21
3. Chandola HM, Kajaria D. Prameha chikitsa adhyaya. In: Baghel MS, Deole YS, Basisht G, editors. Charak samhita new edition. 1st ed. Jamnagar (India): CSRTSDC; 2020. Available from: https://www. carakasamhitaonline.com/index.php?title=prameha_chikitsa [Last accessed on 2026 May 11].
4. Fahed G, Aoun L, Bou Zerdan M, Allam S, Bou Zerdan M, BouferraaY, Assi HI. Metabolic syndrome: Updates on pathophysiology and management in 2021. Int J Mol Sci. 2022;23(2):786. doi: 10.3390/ ijms23020786
5. Berglund L, Brunzell JD, Goldberg AC, Goldberg IJ, Sacks F, MuradMH, Stalenhoef AF, Endocrine Society. Evaluation and treatment of hypertriglyceridemia: An endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2012;97(9):2969-89.
6. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712-7. doi: 10.1016/j. metabol.2008.01.013
7. Mishra A, Sharma K, Pandey J, Dev K, Kadan S, Sahai M, Ahmad I, Srivastava AK, Tamrakar AK, Zaid H, Maurya R. Tinosporaside from Tinospora cordifolia encourages skeletal muscle glucose transport through both PI-3-kinase- and AMPK-dependent mechanisms. Molecules. 2023;28(2):483. doi: 10.3390/molecules28020483
8. Deng S, Xia L, Zhu X, Zhu J, Cai M, Wang X. Natural alphaglucosidase inhibitors rapid fishing from Cyperus rotundus using immobilized enzyme affinity screening combined with UHPLCQTOF MS. Iran J Pharm Res. 2019;18(3):1508-15. doi: 10.22037/ ijpr.2019.1100753
9. Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, Huo L, Wang M, Hong J, Wu P, Ren G, Ning G. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab. 2008;93(7):2559-65.
10. Dhaliwal JS, Spurling BC, Molla M. Tinospora cordifolia. In: StatPearls. Treasure Island, FL: StatPearls Publishing; 2024.
11. Pandit S, Biswas TK, Debnath PK, Saha AV, Chowdhury U, Shaw BP, Sen S, Mukherjee B. Chemical and pharmacological evaluation of different ayurvedic preparations of iron. J Ethnopharmacol. 1999;65(2):149-56.
12. Taylor R. Banting memorial lecture 2012: Reversing the twin cycles of type 2 diabetes. Diabet Med. 2013;30(3):267-75.
