Efficacy of “Shunthi- Gokshur Kwath with Shunthi lepa and Shunthi-Guduchi Kwath with Shunthi lepa” in Management of Rheumatoid Arthritis (Amavata) - Protocol for a Comparative Clinical Study
Keywords:
Ama, Amavata, Shunthi Lepa, Shunthi-Gokshur Kwatha, Shunthi-Guduchi KwathaAbstract
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease with a chronic nature and is associated with significant morbidity in today’s era. The clinical features of RA are analogous to those of the Ayurvedic disease known as Amavata. This is an open-label, randomized clinical study that aims to compare the efficacy of ShunthiGokshur Kwatha with Shunthi Lepa and Shunthi-Guduchi Kwatha with Shunthi Lepa in reducing the disease activity score (DAS) in patients diagnosed with Amavata. A total of 72 participants aged 21–60 years, fulfilling ACR 2010 criteria and exhibiting classical Amavata symptoms, will be randomized into two groups. Group I will receive Shunthi- Gokshur Kwatha with Shunthi Lepa, and Group II will receive Shunthi- Guduchi Kwatha with Shunthi Lepa for a time period of 4 weeks. The primary outcome measure is the DAS-28 score, and the secondary outcome measures are RA factor, C-reactive protein, erythrocyte sedimentation rate, and symptoms of amavata. The assessment of primary and secondary outcome measures will be done at baseline, day 30, and day 60. The study protocol includes randomization, allocation concealment, and proper monitoring to ensure data reliability. The study results will contribute to the integration of Ayurvedic formulation in RA management.
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