A Review on Aging Population and Their Problems and How Traditional Approaches Can Give Support to Overcome These Problems
Keywords:
Antioxidant, Ojascar, Rasayana, Rejuvenation, TriphalaAbstract
Ayurveda has served humanity since ancient times through natural therapeutic approaches. With increasing health awareness, there is a growing preference for naturally derived products over synthetic compounds, which may produce harmful side effects. In this context, plant-based Ayurvedic preparations have gained importance as safer and biodegradable alternatives for the prevention and treatment of various human and plant diseases. Medicinal plants have long been valued for their diverse bioactive constituents and therapeutic potential. Naturally occurring phytochemicals are widely used in the traditional Indian medicinal system of Ayurveda for the treatment of a variety of diseases. Some of the plant products have shown remarkable anti-tumor properties against various human cancers. However, the detailed mechanisms of action of these phytochemicals at the cellular and molecular level have not been fully elucidated. Triphala is a traditional Ayurvedic herbal formulation composed of the fruits of Terminalia chebula, Emblica officinalis, and Terminalia bellirica mixed in equal proportions. It is an important medicine of the “Rasayana” group and is believed to promote health, immunity, and longevity. This formulation, rich in antioxidants, is a frequently used Ayurvedic medicine to treat many diseases, such as anemia, jaundice, constipation, asthma, fever, and chronic ulcers. Most people practicing Ayurvedic medicine consume Triphala as a “health tonic.” Recent studies have reported anti-clastogenic and anti-tumor properties of E. officinalis and the anti-proliferative effect of T. chebula. Triphala Rasayana is an Ayurvedic formulation described in Charaka Samhita and is known for its Rasayana (rejuvenative) effects. Four types of Triphala Rasayana are mentioned in the text. Similar descriptions of Triphala Rasayana are also found in Vagbhat and Bhavaprakasha. In the present study, Triphala churna was subjected to phytochemical investigation using high-resolution mass spectrometry (HRMS) following Soxhlet extraction with a water–ethanol solvent system. The obtained HRMS data were analyzed to identify the major phytoconstituents present in the extract. Subsequently, the identified compounds were screened and validated using the Indian Medicinal Plants, Phytochemistry and Therapeutics Database database (https://cb.imsc.res.in/imppat/) to confirm their phytochemical occurrence and therapeutic relevance. Based on the identified bioactive constituents, an in silico study was designed to evaluate their potential anticancer activity against cancer-associated molecular targets.
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