A Comprehensive Review on Bioactive Compounds of Plant Origin for Anti-arthritic Activities

Authors

  • Abhilasha Chaurasia PhD Scholar, Pharmacogenomics Laboratory, Department of Biosciences, Barkatullah University, Bhopal, Madhya Pradesh, India. Author
  • Aashna Soni BAMS, Dr. Shanker Dayal Sharma Ayurvedic College and Hospital, Bhopal, Madhya Pradesh, India. Author
  • Kapil K. Soni Assistant Professor, Department of Biosciences, Barkatullah University, Bhopal, Madhya Pradesh, India. Author

Keywords:

Arthritis, Bioactive compounds, Inflammation, Phytochemicals, Secondary metabolites

Abstract

The aim of the study of this comprehensive review is to find out the major problems caused by arthritis in common
people. As arthritis is one of the prevalent chronic disorders, that is causing stiffness, pain, and joint dysfunction
including rheumatoid arthritis, septic arthritis, osteoarthritis, and juvenile arthritis. Therefore, there is a basic need
of multidimensional approach for its management. For this, various conventional anti-arthritic drugs such as –
methotrexate and sulfasalazine have been employed to relieve from arthritic conditions, but these drugs have shown
some deleterious effects on human health. This comprehensive review highlights anti-inflammatory potential of
bioactive compounds of plant origin for the management of arthritis.

References

1. Dunlop DD, Manheim LM, Yelin EH, Song J, Chang RW. The costs of arthritis. Arthritis Rheum. 2003;49:101-13.

2. Saleem S, Khan R, Kazmi I, Afzal M. Medicinal plants in the treatment of arthritis. In: Ozturk M, Hakeem KR, editors. Plant and

human health. Vol. 3. London UK: Springer Nature; 2019. p. 101-37.

3. Khaleghi M. New arthritis foundation guidelines on CBD use could be first of many more to come. Altern Thern Health Med.

2020;26:8-11.

4. Sacks JJ, Luo YH, Helmick CG. Prevalence of specific types of arthritis and other rheumatic conditions in the ambulatory health

care system in the United States, 2001-2005. Arthritis Care Res

(Hoboken). 2010;62:460-4.

5. Johnson VL, Hunter DJ. The epidemiology of osteoarthritis. Best Pract Res Clin Rheumatol. 2014;28:5-15.

6. Calabresi E, Petrelli F, Bonifacio AF, Puxeddu I, Alunno A. Oneyear in review 2018: Pathogenesis of rheumatoid arthritis. Clin ExpRheumatol. 2018;36:175-84.

7. Karami J, Aslani S, Jamshidi A, Garshasbi M, Mahmoudi M. Genetic implications in the pathogenesis of rheumatoid arthritis; An updatedreview. Gene. 2019;702:8-16.

8. Ahmed S, Anuntiyo J, Malemud CJ, Haqqi TM. Biological basisfor the use of botanicals in osteoarthritis and rheumatoid arthritis: A review. Evid Based Complement Alternat Med. 2005;2:301-8.

9. Choudhary M, Kumar V, Malhotra H, Singh S. Medicinal plants with potential anti-arthritic activity. J Intercult Ethnopharmacol.

2015;4:147-79.

10. Girija P, Umasankar K, Jupalli Rao JV, Sheshagiri Bandaru SS,Venkateshwarlu E. Anti-arthritic activity of ethanolic extractfrom the leaves of Commiphora caudate (Linn.) in complete Freund′s adjuvant-induced arthritic rats. Niger J Exp Clin Biosci.

2014;2(1):42-8.

11. Kumbhar CM, Patil SY, Yadav PS, Jadhav PH, Metkari VB. Prophylactic effect of hydroalcoholic extract of Colocasia esculenta

leaves in CFA and formaldehyde induced arthritic rats. Asian J Pharm

Res Dev. 2014;2(1):52-9.

12. Alam J, Mujahid M, Badruddeen M, Rahman A, Akhtar J, Khalid M, Jahan Y, Basit A, Khan A, Shawwal M, Iqbal SS. An insight of

pharmacognostic study and phytopharmacology of Aquilaria agallocha. J Appl Pharm Sci. 2015;5(8):173-18.

13. Chaudhary AK, Ahmad S, Mazumder A. Cedrus deodara

(Roxb.) Loud.: A review on its ethnobotany, phytochemical and pharmacological profile. Pharmacogn J. 2011;3(23):12-7.

14. Suh HR, Chung HJ, Park EH, Moon SW, Park SJ, Park CW, Kim YI,

Han HC. The effects of Chamaecyparis obtusa essential oil on painrelated behaviour and expression of pro- inflammatory cytokines in carrageenan-induced arthritis in rats. Biosci Biotechnol Biochem.2016;80(1):203-9.

15. Biradar S, Kangralkar VA, Mandavkar Y, Thakur M, Chougule N. Anti-inflammatory, anti-arthritic, analgesic and anticonvulsant activity of Cyperus essential oils. Int J Pharm Pharm Sci.

2010;2(4):12-5.

16. Uriah T, Rai S, Mohanty JP, Ghosh P. Physicochemical evaluation, in vitro anti-inflammatory, in vitro anti-arthritic activities and GC-MSanalysis of the oil from the leaves of Gaultheria fragrantissima Wall of Meghalaya. J Drug Deliv Ther. 2019;9:170-8.

17. Agrawal RB, Rangari VD. Anti-inflammatory and antiarthritic activities of lupeol and 19α-H lupeol isolated from Strobilanthus

callosus and S. ixiocephala roots. Ind J Pharmacol. 2003;35:384-7.

18. Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives -A review. J Tradit Complement Med. 2017;7(2):205-33.

19. Mittal S, Dixit PK. In-vivo anti-inflammatory and anti-arthritic activity of Asparagus racemosus roots. Int J Pharm Sci Res (IJPSR).2013;4(7):2652-8.

20. Marrelli M, Amodeo V, Peri MR, Conforti F, Statti G. Essential oils and bioactive components against arthritis: A novel perspective on their therapeutic potential. Plants (Basel). 2020;9(10):1252.

21. Gandhi Y, Kumar R, Grewal J, Rawat H, Mishra SK, Kumar V, Shakya SK, Jain V, Babu G, Sharma P, Singh A, Singh R, Acharya R.

Advances in anti-inflammatory medicinal plants and phytochemicals in the management of arthritis. Food Chem Adv. 2022;1:100085.

22. Rathod ZR, Shah D, Shukla P, Meghani S, Patel C, Saraf MS. Citrus limon as an abundant source of phytochemicals: Their evaluation andantioxidant analysis with bacterial endophytes. Curr Trends Biomed Eng Biosci. 2022;20(4):001

23.Babu V, Binwal M, Kumari R, Sen S, Kumar A, Mugale MN, Shanker K, Kumar N, Bawankule DU. Hesperidin-rich ethanol extract from waste peels of Citrus limetta mitigates rheumatoid arthritis and related complications. Phytother Res. 2021;35:3325-36.

24.Thakur AV, Ambwani S, Ambwani TK, Ahmad AH, Rawat DS. Evaluation of phytochemicals in the leaf extract of Clitoria ternatea wild through GC-MS analysis. Trop Plant Res. 2018;5(2):200-6.

25.Swathi KP, Jayaram S, Sugumar D, Rymbai E. Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea. Chin Herb Med. 2021;13:243-9.

26.Shirodkar SM, Multisona RR, Michalowska AG. The potential for the implementation of pea flower (Clitoria ternatea) health properties in food matrix. Appl Sci. 2023;13:7141.

27.Singh NK, Gupta JK, Shah K, Mishra P, Tripathi A, Chauhan NS, Upmanyu N. A review on Clitoria ternatea (Linn.): Chemistry and pharmacology. In: Medicinal Plants and Its Therapeutic Uses. United States: OMICS Group eBooks; 2017.

28.Amorim JL, Simas DL, Pinheiro MM, Moreno DS, Alviano CS, Da Silva AJ, Fernandes PD. Anti-inflammatory properties and chemical characterization of the essential oils of four Citrus species. PLoS One. 2016;11(4).

29.Tag HM, Kelany OE, Tantawy HM, Fahmy AA. Potential anti-inflammatory effect of lemon and hot pepper extracts on adjuvant-induced arthritis in mice. J Basic Appl Zool. 2014;67:149-57.

30.Bekkouch O, Zengin G, Harnafi M, Touiss I, Khoulati A, Saalaoui E, Harnafi H, Abdellattif H, Amrani S. Anti-inflammatory study and phytochemical characterization of Zingiber officinale Roscoe and Citrus limon L. juices formulation. ACS Omega. 2023;8:26715-24.

31.Dara H, Dinesh DS, Ravichander T. Evaluation of analgesic and anti-inflammatory activity of Citrus limon peel in albino Wistar rats. Int J Chem Pharm Sci. 2017;5(6):165-9.

32.Vaishnav GV, Chavan GC, Shirsat MK. Formulation and evaluation of antimicrobial gel of Clitoria ternatea (flowers). J Surv Fish Sci. 2023;10(1):3216-21.

33.Mariano FI. Antioxidant and anti-arthritic activity of peels from Citrus fruits. J Pharmacol Phytochem. 2023;12(6):329-36.

34.Bhatia M, Chahal J, Gupta S. Analgesic and anti-inflammatory activities of Clitoria ternatea (L.) leaves extract on rat model. Int J Pharm Sci Res. 2014;5(2):600-6.

35. Chandanshive A, Tamboli A, Karande P, Bahire S, Bhosale M. In vitro anti-arthritic activity of Citrus peel. Int J Adv Eng Manag.

2020;2(4):529-35.

36. Cano EM, Cano SM, Lopez KI, Simental JA. Preliminary phytochemical study and TLC analysis of the fruit, leaves and

flowers of Citrus limetta Risso. J Pharmacogn Phytochem. 2017;6(5):594-9.

37. Bhattacharya S, Mandal SK, Akhtar MD, Dastider D, Sarkar S, Bose S, Bose A, Mandal S, Kolay A, Sen DJ, Kumar A, Pan S,

Pramanick A. Phytochemicals in the treatment of arthritis: Current knowledge. Int J Curr Res. 2020;12(4):1-16.

38. Available from: https://pubchem.ncbi.nlm.nih.gov/#query=Taraxerol [Last accessed on 2026 May 13].

39. Available from: https://pubchem.ncbi.nlm.nih.

gov/#query=Taraxerone [Last accessed on 2026 May 13].

40. Available from: https://pubchem.ncbi.nlm.nih.gov/#query=BSitosterol [Last accessed on 2026 May 13].

41. Available from: https://pubchem.ncbi.nlm.nih. gov/#query=kaempferol [Last accessed on 2026 May 13].

42. Available from: https://pubchem.ncbi.nlm.nih.gov/#query=Clitorin [Last accessed on 2026 May 13].

43. Available from: https://pubchem.ncbi.nlm.nih. gov/#query=%22Myricetin%203'-glucoside%22 [Last

accessed on 2026 May 13].

44. Available from: https://pubchem.ncbi.nlm.nih.gov/#query=adenosine [Last accessed on 2026 May 13].

45. Available from: https://pubchem.ncbi.nlm.nih.gov/#query=curcumin [Last accessed on 2026 May 13].

46. Available from: https://pubchem.ncbi.nlm.nih.gov/#query=berberin [Last accessed on 2026 May 13].

47. Available from: https://pubchem.ncbi.nlm.nih. gov/#query=Thymoquinone [Last accessed on 2026 May 13].

48. Available from: https://pubchem.ncbi.nlm.nih.gov/#query=kirenol [Last accessed on 2026 May 13]

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2026-07-31

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